Preheat your oven to 350°F (175°C).

Cook the penne pasta according to package instructions until al dente. Drain and set aside.

In a large pot, melt the butter over medium heat.

Whisk in the flour and cook for about 1 minute until golden.

Gradually whisk in the milk, stirring constantly until the mixture thickens.

Remove from heat and stir in the white cheddar and mozzarella until melted and smooth.

Add garlic powder, onion powder, salt, and pepper, and mix well.

In a large mixing bowl, combine the cooked pasta and cheese sauce, mixing until the pasta is well coated.

Transfer the mixture to a greased baking dish.

In a small bowl, mix the breadcrumbs and Parmesan cheese, then sprinkle over the pasta.

Bake in the preheated oven for 20-25 minutes until golden and bubbly.

Let cool for a few minutes before serving.